Premium
Effects of race and periodontal status on antibody reactive with Actinobacillus actinomycetemcomitans strain Y4
Author(s) -
Gunsolley J. C.,
Tew J. G.,
Gooss C. M.,
Burmeister J. A.,
Schenkein H. A.
Publication year - 1988
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1988.tb01421.x
Subject(s) - periodontitis , actinobacillus , medicine , population , antibody , aggressive periodontitis , immunology , environmental health
Higher levels of serum antibody reactive with Actinobacillus actinomycetemcomitans strain Y4 (AAY4) have been demonstrated in localized juvenile periodontitis than in other forms of periodontal diseases. However, in studies which reported the racial distribution of the clinical groups, a predominantly black juvenile periodontitis population has been compared with a non‐periodontitis control population that was predominantly white. The purpose of this study was to determine the effect of race (black or white) on antibody reactivity to AAY4 for subjects with clinical diagnoses of adult periodontitis (AP), non‐periodontitis (NP), juvenile periodontitis (JP) and severe generalized periodontitis in young adults (SP). A radioimmunoassay (RIA) was utilized to detect and quantitate antibody to AAY4. Within clinical groups of NP, JP and SP a higher prevalence of seropositive black subjects than white subjects was found. The association between a high prevalence of positive antibody responses to AAY4 in JP subjects compared to NP subjects still exists, but was reduced compared to previous reports. White non‐periodontitis subjects, used as control subjects in previous reports, were found to have a significantly lower frequency of seropositivity to AAY4 than black non‐periodontitis subjects. This relationship held whether the periodontatly healthy subject was ascertained from a family with a JP or SP family member or was ascertained solely on the basis of a diagnosis of non‐periodontitis. The difference in the prevalence of seropositivity to AAY4 between JP and SP subjects was entirely due to the racial composition of the two groups, as nearly half the SP subjects were white compared with only 15% of the JP subjects. Thus, antibody reactivity to AAY4 was found to be related to both clinical diagnosis and race.