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Injection of an antigen into the gingiva and its effect on an experimentally induced inflammation in the knee joint of the mouse
Author(s) -
Lens Jan Willem,
Beertsen Wouler
Publication year - 1988
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1988.tb01018.x
Subject(s) - inflammation , antigen , arthritis , medicine , knee joint , immune system , immunology , pathology , surgery
Antigen was injected into the gingiva and tested for its ability to induce a flare of a chronic arthritis. Joint inflammation was established by a local injection of 100 μg methylated bovine serum albumin (mBSA) in the right knee joint of immune mice. About 4 wk later, 0·5‐1 mg mBSA was injected into the gingiva. It was found that this antigenic challenge induced a flare of the arthritis as measured with the 99m Technetium ( 99m mTc) uptake method. Light microscopic examination of the knee joints revealed an increase of inflammatory cells in the synovial tissue and the joint space. The results indicate that, under certain experimental conditions, antigenic material administered to the gingiva can influence an inflammation elsewhere in the body.