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Effect of spiramycin therapy on human periodontal disease
Author(s) -
Sznajder N.,
Piovano S.,
Bernat M. I.,
Flores L.,
Macchi R.,
Carraro J. J.
Publication year - 1987
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1987.tb01582.x
Subject(s) - spiramycin , placebo , medicine , dentistry , oral hygiene , gingival and periodontal pocket , periodontal disease , antibiotics , pathology , biology , microbiology and biotechnology , alternative medicine , erythromycin
The aim of this study was to evaluate the effect of spiramycin on subgingival microflora and periodontal tissues in 10 patients, divided into 2 groups of 5 patients each, with 14 sites studied in each group. The 28 sites were examined at baseline, immediately before drug or placebo intake and then 2 and 4 weeks later. The assessment included oral hygiene status, gingival conditions, bleeding on probing, crevicular fluid and morphotype count by darkfield microscopy. On a double blind basis, patients received, at random, placebo (control group) or spiramycin (test group) 3 g the first day and 2 g daily during a fortnight. In the test group, results at 2 wk examination showed a statistically significant increase (p<0.05) in coccoid cells, and reduction of motile rods and spirochetes, as well as pocket depth decrease. Plaque Index, Gingival Index and Crevicular Fluid only changed at 4 wk examination. No changes were recorded for the control group. The above improvements were maintained up to 15 d following drug administration. The authors suggest that spiramycin could be used profitably as an adjunct to mechanical therapy in reducing the periodontopathic flora.