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Local Shwartzman activity of lipopolysaccharides from several selected strains of suspected periodontopathic bacteria
Author(s) -
Koga Toshihiko,
Odaka Chikako,
Moro Itaru,
Fujiwara Taku,
Nishihara Tatsuji,
Okahashi Nobuo,
Hamada Shigeyuki
Publication year - 1987
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1987.tb01547.x
Subject(s) - fusobacterium nucleatum , actinobacillus , microbiology and biotechnology , shwartzman phenomenon , lesion , escherichia coli , bacteroidaceae , bacteroides , lipopolysaccharide , fusobacterium , bacteria , chemistry , periodontitis , biology , porphyromonas gingivalis , immunology , medicine , pathology , biochemistry , genetics , gene
Lipopolysaccharides (LPSs) were isolated from Fusobacterium species, Bacteroides species, Actinobacillus actinomycetemcomitans and Escherichia coli by the phenol water procedure, and their capacity to induce the local Shwartzman reaction was determined. Preparatory and provoking injections of homologous LPS preparations caused LPSs from E. coli and F. nucleatum to induce a hemorrhagic necrosis, indicating a typical Shwartzman reaction. On the other hand, LPSs from A. actinomycetemcomitans and B. gingivalis induced a weak inflammatory lesion, but no necrotic lesion. The provoking activities of LPSs from F. nucleatum and A. actinomycetemcomitans in inducing an inflammatory lesion were comparable to that of LPS from E. coli , but the activity of LPS from B. gingivalis was low. The preparatory activities of LPSs from B. gingivalis and B. oralis in inducing an inflammatory lesion were comparable to those of LPSs from F. nucleatum, F. necrophorum and A. actinomycetemcomitans .