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Flurbiprofen treatment of periodontal disease in beagles
Author(s) -
Jeffcot M. K.,
Williams R. C.,
Wechter W. J.,
Johnson H. G.,
Kaplan M. L.,
Gandrup J. S.,
Goldhaber P.
Publication year - 1986
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1986.tb01499.x
Subject(s) - flurbiprofen , beagle , medicine , dental alveolus , placebo , dentistry , anesthesia , pathology , alternative medicine
The effect of the non‐steroidal anti‐inflammatory drug flurbiprofen on the progression of periodontal disease was studied in 12 beagle dogs over a 2‐yr period. Standardized radiographs were used to measure the rate of bone loss; bone‐seeking radiophormaceutical uptake was used to assess the effect on bone metabolism, and gingival inflammation was scored. Following a 6‐month pretreatment baseline period. 6 dogs were dosed daily with 0.02 mg/kg flurbiprofen for a 12‐month treatment period. Also, one side of the mouth in each dog was treated with periodontal flap surgery at the beginning of the treatment period. After 12 months, flurbiprofen was discontinued and the dogs were studied for a 6‐month post‐treatment period. In flurbiprofen‐treated dogs the rate of bone loss was significantly decreased about both surgically and non‐surgically treated teeth throughout the 12‐month treatment period. This decreased rate was sustained through 3 months of the post‐treatment period, but was lost 6 months following the termination of flurbiprofen therapy. No similar effect on reducing the rate of bone loss was observed in the placebo‐treated dogs. A significant decrease in bone‐seeking radiopharmaceutical uptake was observed in the flurbiprofen‐treated teeth, which corresponded with the radiographic findings. Changes in gingival inflammation with flurbiprofen treatment were not observed. These data indicate that flurbiprofen is a potent inhibitor of alveolar bone loss in beagles and within 6 months of the termination of flurbiprofen the effect on slowing the rate of bone loss is lost.