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A reassessment of collagen half‐life in rat periodontal tissues: Application of the pool‐expansion approach
Author(s) -
Imberman M.,
Ramamurthy N.,
Golub L.,
Scineir M.
Publication year - 1986
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1986.tb01473.x
Subject(s) - periodontal fiber , molar , incisor , chemistry , in vivo , dentistry , collagen fiber , anatomy , medicine , biology , microbiology and biotechnology
Pool expansion ‐ a method for measuring in vivo collagen production that involves injection of excess unlabeled proline along with [3H]proline ‐ was used to calculate the values for collagen half‐life in rat: incisor and molar periodontal ligament, molar gingiva and palatal mucosa. Collagen in most periodontal tissues (except for incisor gingiva) turns over more rapidly than skin collagen. The results reaffirm the concept that collagen in most periodontal tissues turns over with unusual rapidity.