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A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth
Author(s) -
Terranova Victor P.,
Franzetti Louis C.,
Hic Susanne,
Diflorio Roberta M.,
Lyall Raymond M.,
Wikesjö Ulf M. E.,
Baker Pamela J.,
Christersson Lars A.,
Genco Robert J.
Publication year - 1986
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1986.tb01467.x
Subject(s) - dentin , fibronectin , connective tissue , fibroblast , chemistry , adhesion , regeneration (biology) , dentistry , wound healing , microbiology and biotechnology , cell , medicine , biochemistry , pathology , biology , in vitro , immunology , organic chemistry
One objective of periodontal therapy after resolution of the infectious process is to facilitate a new connective tissue attachment to the root dentin surface. Here we report that a selective advantage for attachment and growth can be conferred on human gingival fibroblasts by biochemical manipulation of the dentin surface. Tetracycline HCL treatment of the dentin surface increases binding of fibronectin. The adsorbed fibronectin stimulates fibroblast attachment and growth, while suppressing epithelial cell attachment and growth. This biochemical manipulation may provide a useful approach for the treatment of periodontally involved teeth.