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Effects of experimental diabetes mellitus on alveolar bone loss in periodontal disease‐susceptible mice
Author(s) -
Johnson Roger B.
Publication year - 1985
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1985.tb00439.x
Subject(s) - dental alveolus , diabetes mellitus , medicine , resorption , interdental consonant , bone resorption , endocrinology , alveolar crest , periodontitis , dentistry
The purpose of this study was to determine the effects of experimental diabetes mellitus on alveolar bone in an animal predisposed to alveolar bone resorption, the STR/N strain of mice. Animals, aged twelve weeks, were rendered diabetic by an intravenous injection of streptozotocin, and bone loss was measured in the interdental septum between the first and second molar teeth. Prior to eighteen weeks, there was no consistent pattern of bone loss in either group. After eighteen weeks, bone loss in the diabetic group was significantly less (p<0.001) than in the control group. This situation was evident during the remainder of the thirty‐week study. Bone loss was a result of resorption of the alveolar crest resulting in an increased width of the transseptal fiber group. Alcian blue stain, pH 1.0, a histochemical marker for sulfated glycosaminoglycans, indicated a progressive decrease in bone matrix glycosaminoglycans in diabetic animals. However, intense alcian blue positive areas at the bone periphery suggested that glycosaminoglycans were not depleted in those areas. The study suggests that diabetes mellitus does not increase alveolar bone loss in susceptible animals, possibly because the diabetic condition was established subsequent to the initiation of alveolar bone resorption.