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Microtubules in periodontal ligament cells in relation to tooth eruption and collagen degradation
Author(s) -
Beertsen W.,
Everts V.,
Hoeben K.,
Niehof A.
Publication year - 1984
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1984.tb01304.x
Subject(s) - periodontal fiber , microtubule , dentistry , medicine , microbiology and biotechnology , biology
The effects of the anti‐microlubular drug colchicine on the eruption of the continuously growing mouse incisor and the structure of its periodontal ligament, which is thought to be responsible for generating the eruptive force were studied. It was observed that both the eruptive process and the microtubular apparatus in the cells of the ligament are affected by the drug in a dose‐dependent fashion, thereby lending support to the view that eruption is related to the functioning of microtubules in periodontal ligament cells. Since colchicine did not seem to interfere with collagen degradation. as measured in terms of collagen phagocytosis by fibroblasts and loss of connective tissue attachment in the supra‐alveolar region, the inhibition of eruption is not likely to be due to an increased resistance force in the periodontal ligament as a result of decreased collagen breakdown.