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Prostaglandin activity and sulcular flow in carrageenan‐injected gingiva of the dog
Author(s) -
Yoda W.,
Sproat R.,
Izutsu K.T.,
Siegel I.A.
Publication year - 1984
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1984.tb01191.x
Subject(s) - antihistamine , prostaglandin , pyrilamine , gingivitis , prostaglandin e2 , carrageenan , prostaglandin e , medicine , chemistry , dentistry , endocrinology , anesthesia , pharmacology , receptor , antagonist
Intragingival injection of one percent carrageenan solution in anesthetized dogs caused an increase in prostaglandin‐like activity in the injected gingiva and a two phase increase in sulcular flow. The first phase was not inhibited by either the prostaglandin synthetase inhibitor indomethacin or the antihistamine pyrilamine. The second phase of increased flow, which was temporally correlated with increased gingival prostaglandin‐like activity, was inhibited by indomethacin, but not by pyrilamine. These results suggest that the increase in gingival sulcular flow in this model of inflammation may be, at least in part, related to increased prostaglandin concentrations.