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A quantitative analysis of connective tissue components in phenytoin‐induced gingival overgrowth in children
Author(s) -
Dahllöf G.,
Reinholt F. P.,
Hjerpe A.,
Modér T.
Publication year - 1984
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1984.tb01013.x
Subject(s) - phenytoin , connective tissue , lesion , interdental consonant , matrix (chemical analysis) , pathology , medicine , anatomy , dentistry , chemistry , epilepsy , chromatography , psychiatry
A stereological analysis of connective tissue components in phenytoin‐induced gingival overgrowth in children was performed. The volume density (V v ) of the different components was calculated by point counting on semi‐thin sections of interdental papillae from children (n=12) between 8 and 14 years old. This study shows a statistically significant increase in the non‐collagenous matrix V v and a corresponding decrease in the collagenous matrix V v in the phenytoin‐enlarged gingiva compared to controls. These results indicate that the PHT‐induced lesion represents a tissue with an altered composition of the connective tissue.