Premium
Neutrophil chemotaxis and phagocytosis in juvenile periodontitis
Author(s) -
Ellegaard B.,
Borregaard N.,
Ellegaard J.
Publication year - 1984
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1984.tb00817.x
Subject(s) - phagocytosis , antibody opsonization , chemotaxis , zymosan , opsonin , periodontitis , immunology , superoxide , lysozyme , juvenile , microbiology and biotechnology , biology , chemistry , medicine , biochemistry , enzyme , in vitro , receptor , genetics
Detailed quantitative studies of phagocytosis were performed on purified blood neutrophils isolated from 12 young and 10 adult patients with advanced periodontitis and from 22 age and sex matched controls without periodontitis. Chemotaxis was significantly reduced only in the young patients whereas no difference could be demonstrated between young and adult patients or controls in uptake of opsonized zymosan particles, in the concentration and consumption rate of ATP, in the rate of oxygen consumption and superoxide liberation, or in the exocytosis of β‐glucuronidase and lysozyme during phagocytosis. Serum opsonization was equally effective in the 3 groups. It is concluded that defective chemotaxis in juvenile periodontitis does not originate from defective mobilization of energy in the neutrophils during active movements.