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Cell turnover in the periodontium in health and periodontal disease
Author(s) -
Gould T. R. L.,
Brunette D. M.,
Dorey J.
Publication year - 1983
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1983.tb00370.x
Subject(s) - periodontal fiber , periodontium , periodontal disease , cell , thymidine , disease , medicine , biology , pathology , endocrinology , microbiology and biotechnology , dentistry , biochemistry , dna
The use of tritiated thymidine labelling given by continuous delivery over long periods by means of an implanted osmotic minipump is a convenient method of accurately determining the rate of cellular proliferation in various tissues, but is especially advantageous for the periodontal ligament (PDL), the fibroblasts of which turn over at an extremely low rate. This technique was used to examine the hypothesis that differences exist between cell turnover in normal hamsters (N.D.) and those which had been placed on a periodontal disease inducing diet (S.S.D.). Turnover rates were then calculated for PDL and epithelial attachment (EA) for N.D and S.S.D animals before and after disease had been induced. No effect of disease was noted for either PDT or EA. However, the technique was sufficiently sensitive to demonstrate a significant effect of age on the turnover of cells in the epithelial attachment.