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Periodontal bone loss in ovalbumin sensitized germfree rats fed antigen‐free diet with ovalbumin
Author(s) -
Taubman Martin A.,
Buckelew Julia M.,
Ebersole Jeffrey L.,
Smith Daniel J.
Publication year - 1983
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1983.tb00362.x
Subject(s) - ovalbumin , antigen , immune system , antibody , saliva , endocrinology , medicine , immunology , antibody response , biology
The cellular and humoral responses in ovalbumin (OVA) presensitized germfree rats fed OVA (SAF), in an otherwise antigen‐free diet, were compared to sham‐sensitized animals that were also fed OVA (SSAF). Sensitized animals demonstrated relatively more lymphocytes in their gingival tissues. An initial predominance of T lymphocytes gave way to a predominance of B‐lymphocytes. Splenic lymphocytes from presensitized animals showed significant blastogenesis at the time antigen feeding was initiated. Sensitized animals showed elevated blastogenesis throughout the feeding period whereas the sham‐sensitized animals showed some elevated responses only after 38 days of antigen feeding. The plasma IgG response to OVA was markedly elevated in the sensitized animals, in contrast to a low or nonexistent IgG antibody response in the sham‐sensitized rats. On the other hand, IgA anti‐OVA responses in intestinal perfusates were elevated in the SAF group for the first 14 to 21 days of feeding. Early salivary IgA responses (0 to 21 days) were essentially the same between the groups, but later (38 to 84 days) both IgA and IgG responses in saliva were elevated in the SAF group. Sensitized animals demonstrated significantly elevated periodontal bone loss after 84 or 128 days of OVA feeding. The potential effects of “mixed” hypersensitivity on periodontal disease in the rat are discussed.