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Effect of indomethacin on bone destruction during experimental periodontal disease in the hamster
Author(s) -
Lasfargues JeanJacques,
Saffar JeanLouis
Publication year - 1983
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1983.tb00342.x
Subject(s) - dental alveolus , bone resorption , periodontitis , hamster , resorption , osteoclast , prostaglandin e2 , calcitonin , prostaglandin , endocrinology , medicine , prostaglandin e , periodontal disease , in vitro , chemistry , dentistry , biochemistry , receptor
A major event in periodontitis is the destruction of alveolar processes. It is demonstrated that indomethacin (IND), an inhibitor of prostaglandin synthesis, can inhibit bone resorption in vitro . The aim of this study was to test the effect of IND on bone destruction in hamster periodontal disease. Its action was compared to calcitonin (CT), an inhibitor of osteoclastic resorption. IND decreased the macroscopic bone loss by 28% and the number of osteoclasts per mm by 55% in diseased animals but not significantly. Conversely CT reduced significantly bone loss (p<0.05) and decreased the number of osteoclasts to the control level (p<0.01). The combination of the two drugs had the same effect than CT alone on the two parameters. These results show an effect of IND on bone destruction but an inhibitory action on prostaglandin synthesis can only be hypothesized. In this model of periodontitis CT appears more effective than IND.