Premium
Inhibition of post‐extraction alveolar ridge resorption in rats by dichloromethane
Author(s) -
Olson H. M.,
Hagen A.
Publication year - 1982
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1982.tb01188.x
Subject(s) - dichloromethane , resorption , dental alveolus , extraction (chemistry) , alveolar ridge , molar , medicine , dentistry , bone resorption , dental extraction , chemistry , chromatography , surgery , solvent , biochemistry , implant
The therapeutic effect of dichloromethane diphosphonate (C1 2 MDP) on postdental extraction alveolar bone resorption was studied in rats. Rais were injected with 10 mg Cl 2 MDP/kg/day s.c. for varying intervals from seven days prior to, through 27 days after extraction of maxillary molar teeth. Results demonstrated that C1 2 MDP effectively inhibited rapid alveolar bone loss even after a brief interval of therapy (seven days of therapy prior to extraction), suggesting that the efficacy is not immediately reversible.