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Tetracycline treatment of periodontal disease in the beagle dog
Author(s) -
Jeffcoat M. K.,
Williams R. C.,
Kaplan M. L.,
Goldhaber P.
Publication year - 1982
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1982.tb01175.x
Subject(s) - tetracycline , beagle , dental alveolus , medicine , bone remodeling , dentistry , antibiotics , chemistry , biochemistry
Bone‐seeking radio pharmaceutical uptake (BSRU) was used to examine alveolar bone metabolism in a longitudinal study of tetracyclinc efficacy ID beagle dogs. BSRU was measured in untreated control dogs and in beagles receiving either 250 mg or 500 mg oral tetracycline‐HCI daily for 16 months. The rate of boneless was determined from radiographs taken semiannual!)’for a 6‐month pretremment period and for a 24‐month treatment period. Measurements of BSRU obtained ai month 16 of treatment were correlated with rates of bone loss determined radiographically in an attempt to determine whether BSRU was indicative of the subsequent rate of boneless. A reduced rate of alveolar bone loss was found in the 500 mg tetracycline group at month 16 of the study relative to the untreated controls which was consistent with the decreased bone‐seeking radio pharmaceutical uptake observed in this group. A significantly increased BSRU (p < .0001) was found in the 250 mg tetracycline group at month 16 of study relative to the untreated and 500 mg tetracycline groups. A rapid increase in the rale of bone loss in the 250 mg tetracycline group which was not detectable prior to 16 months of treatment became evident radiographically by 24 months. Thus, increased BSRU in the 250 mg teiracyclinc group appeared to detect the loss of the effect of telracycline on reducing the rate of alveolar bone resorplion in these beagles several months prior to radiographic evidence of the loss of the effect of tetracycline (escape phenomenon).