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New sustained release dosage form of chlorhexidine for dental use
Author(s) -
Friedman Michael,
Golomb Gershon
Publication year - 1982
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1982.tb01160.x
Subject(s) - chlorhexidine , ethyl cellulose , polyethylene glycol , chemistry , chloroform , ethanol , resorcinol , dosage form , polyethylene , kinetics , nuclear chemistry , chromatography , casting , dentistry , materials science , organic chemistry , polymer , composite material , medicine , physics , quantum mechanics
The purpose of this study was to develop a sustained release dosage form of chlorhexidine diacetate for topical use. Cast films of ethyl cellulose with or without polyethylene glycol containing 5, 10, and 20 % of the drug were prepared and exhibited sustained release. Chloroform and ethanol were used as casting solvents. Release rate of chlorhexidine from the film was measured by means of a UV spectrophotometer, and kinetics of release were found to conform to Higuchi's diffusional model. This study demonstrates that by embedding chlorhexidine in polymeric films it is possible to obtain sustained release of the drug for several months.