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Collagen degradation by human gingival fibroblasts
Author(s) -
Yamasaki Akira,
Rose George G.,
Mahan Charles J.
Publication year - 1981
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1981.tb00980.x
Subject(s) - connective tissue , lamina propria , pathology , phagocytosis , chemistry , periodontitis , fibroblast , medicine , epithelium , immunology , in vitro , dentistry , biochemistry
An electron microscopic survey and stereological analysis were made of the lamina propria of human gingival tissues from 8 patients with periodontitis and 6 patients clinically free of pathology (normal). The connective tissue was classified and divided into Zones A, B, and C, according to their collagen content, fibroblastic status (active or inactive), and numbers of inflammatory cells. Fibroblastic phagocytosis of collagen was most prominent in relatively stable areas (Zone A) where the collagen content was high, fibroblasts were classified as inactive (resting), and there were no inflammatory cells. Active (synthesizing) fibroblasts were conspicuous in Zone B, where intercollagenous spaces were wide and mononuclear cells occurred. Phagocytosis of collagen in the human gingiva was found to be a minor function of fibroblasts in Zone B and the highly inflamed Zone C.