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Peripheral blood leucocytes with receptors for extracts of dental plaque
Author(s) -
Hardy G.,
Walker D. M.,
Guest P.
Publication year - 1981
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1981.tb00965.x
Subject(s) - antigen , phagocytosis , immunology , receptor , peripheral blood , antibody , biology , microbiology and biotechnology , biochemistry
The proportions of T and B lymphocytes, monocytes and polymorphs have been investigated in blood leucocytes expressing receptors for plaque antigens. In both patients with periodontal disease and in normal subjects, at least 95 per cent of the antigen binding leucocytes were found to be T lymphocytes. Only a mean 2 percent of the leucocytes from diseased and normal groups were B lymphocytes according to their membrane immunoglobulin. Antigen binding monocytes or polymorphs detected by phagocytosis were uncommon (a mean of 0 and 2 per cent for patients and normal subjects respectively). No differences were found between the proportions of T and B lymphocytes or phagocytic cells constituting the antigen binding leucocytes in patients or controls. There is no evidence of clonal deletion or receptor blockade of a particular subpopulalion of leucocytes amongst the antigen binding cells in severe periodontal disease.