Premium
The inhibition of human gingival collagenase by an inhibitor extracted from human teeth
Author(s) -
Geiger Selly B.,
Harper Elvin
Publication year - 1981
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1981.tb00944.x
Subject(s) - collagenase , microbial collagenase , chemistry , size exclusion chromatography , biochemistry , microbiology and biotechnology , enzyme , biology
The activity of human gingival collagenase was inhibited by an inhibitor found in an extract of human teeth. This inhibitor, denoted Human Dental Collagenase Inhibitor, was partially purified and found to selectively inhibit human skin and gingival collagenase, as well as tadpole collagenase, but not the bacterial collagenase ( Clostridium histolyticum ). On the basis of gel filtration analysis we determined that the inhibitor has an apparent molecular weight of approximately 12,000 daltons, similar to that reported for other tissue collagenase inhibitors.