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Inflammatory reactions in the gingival region during the development of bacterial plaque in alloxan‐diabetic dogs
Author(s) -
Matsson L.,
Attstrom R.,
Granath L.
Publication year - 1980
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1980.tb00309.x
Subject(s) - alloxan , medicine , diabetic ulcers , gingival inflammation , diabetes mellitus , dentistry , gingivitis , diabetic foot , endocrinology
The effect of experimentally induced diabetes on inflammatory reactions in the gingival region of the beagle dog has been studied in connection with the development of dental plaque. The investigation, which was undertaken in 5 dogs, had an intra‐individual design, the increases in the amounts of gingival exudate and crevicular leukocytes during plaque development being studied in each animal before and after the induction of alloxan‐diabetes. The increases in gingival exudate and crevicular leukocytes in response to plaque accumulation showed a tendency to be lower during diabetic compared with non‐diabetic periods. It is suggested that the lower vascular reaction and the reduced leukocyte migration that were observed shortly after onset of the experimental diabetes might reflect an impaired defense mechanism of importance in the longer run for the development of pathological changes in the periodontium.