Premium
Stimulation of lysosomal enzyme release from macrophages by lipoteichoic acid
Author(s) -
Harrop P. J.,
O'Grady R. L.,
Knox K. W.,
Wicken A. J.
Publication year - 1980
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1980.tb00307.x
Subject(s) - lipoteichoic acid , acid phosphatase , cycloheximide , enzyme , secretion , biochemistry , collagenase , in vitro , alkaline phosphatase , lysosome , microbiology and biotechnology , chemistry , biology , bacteria , protein biosynthesis , staphylococcus aureus , genetics
Preparations of lipoteichoic acid (LTA) from strains of streptococci and lactobacilli were examined for their ability to stimulate the release of enzymes from rat peritoneal macrophages in vitro. The three lysosomal enzymes, acid phosphatase, N‐acetyl‐β‐D‐glucosamini‐dase and β‐galactosidase, were detected but not collagenase. Generally, the secretion of the lysosomal enzymes was not inhibited by cychloheximide, indicating that only preformed enzyme was being released. In contrast, cycloheximide partially inhibited the release of lysosomal enzymes by lipopolysaccharides (LPS).