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Salivary volatiles as indicators of periodontitis
Author(s) -
Kostelc J. G.,
Preti G.,
Zelson P. R.,
Stoller N. H.,
Tonzetich J.
Publication year - 1980
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1980.tb00273.x
Subject(s) - saliva , periodontitis , chemistry , etiology , pyridine , urea , medicine , chromatography , gastroenterology , biochemistry , organic chemistry
Volatile organic compounds in mouth air and saliva are useful in diagnosis of several systemic pathologies. Specific oral metabolites (ammonia, urea, volatile sulphur compounds) have been suggested as possible diagnostic and contributory factors to the etiology or pathogenesis of periodontitis. In this study, volatile organic compounds are characterized by gas chromatography/mass spectrometry from the headspace of incubated whole saliva from subjects with essentially normal oral health and subjects with moderate to severe periodontitis as rated by four oral health indices. Several compounds including aliphatic and aromatic alcohols, indole and dimethyl disulfide appear common to all subjects. Moreover, aromatic nitrogen containing compounds, i.e., pyridine and picolines, appear only in subjects with moderate to severe periodontitis. The occurrence of pyridine and picolines in the salivary volatiles of diseased subjects suggests that they are related to the disease process.