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The distribution of HLA‐A and ‐B antigens in patients and their families with periodontosis
Author(s) -
Cullinan Mary P.,
Sachs J.,
Wolf E.,
Seymour G. J.
Publication year - 1980
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1980.tb00272.x
Subject(s) - ethnic group , human leukocyte antigen , biology , haplotype , immunology , antigen , genetics , allele , gene , sociology , anthropology
To test the hypothesis of an association between periodontosis and the HLA‐complex, 30 unrelated patients and 8 families were tissue typed for HLA‐A and ‐B antigens. The patients were divided in two groups on an ethnic basis. Control groups consisted of unrelated individuals of the same ethnic origin. In the Negroid group I a statistically significant increase in the frequency of HLA‐BW35 was found. However, this significance was not apparent when compared to a control group matched for geographical location as well as ethnic origin. No statistically significant differences were observed in the Caucasoid group II. The segregation patterns of HLA and periodontosis in the families were not conclusive. Establishing whether unaffected younger siblings of the patients will develop periodontosis in the future complicated the analysis. More family studies are needed to assess whether the distribution of HLA haplotypes in affected siblings is indeed random as suggested by our data or not.