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Evidence suggesting the presence of antigen‐antibody complexes on the surface of salivary leukocytes
Author(s) -
Sonis S. T.,
Mirando D. M.,
Lamster I. B.,
Stelos P,
Wilson R.E.
Publication year - 1979
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1979.tb00233.x
Subject(s) - antibody , immune system , receptor , antigen , population , immunology , saliva , salivary gland , cell , biology , peripheral blood , chemistry , medicine , biochemistry , environmental health
Fc receptors of salivary leukocytes were studied in twelve patients using sheep red blood cell rosetting techniques. The number of salivary leukocytes having funcitonal Fc receptors was less than expected and was thought to be due to the presence of antigen‐antibody complexes on the surface of leukocytes. Since immune complexes are known activators of neutrophils, we hypothesized taht glucose metabolism in the hexose monophosphate shunt by salivary neutrophils should be greater than a comparable cell population from peripheral blood. Using an assay to assess the metanolism of 14c‐labeled glucose, it was found that salivary leukocytes were more active than peripheral blood leukocytes and that the ability of salivary leukocytes to be extrinsically activated was less than peripheral blood leukocytes. The data suggests that immune complexes area probably present on the surface fo salivary leukocytes and that such complexes are able to modify the surface receptors and functional capacity of these cells.