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Modulation of gingival cAMP levels by tissue infalmmation
Author(s) -
Grower Marvin F.,
Chandler Dorothy
Publication year - 1979
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1979.tb00217.x
Subject(s) - gingival inflammation , basal (medicine) , hard tissue , gingival disease , gingivitis , dentistry , medicine , endocrinology , insulin
The basal levels of the nucletide cAMPin gingiva and the relationship of these levels to gingival tissue health was determined in Rhesus monkeys. It was shown that tissue cAMP levels were negatively correlated ot gingival infalmmation. Infalmed gingiva showed lower tissue cAMP levels that healthy gigiva. In adition, the effect of thetrauma of in the tissues progressively decreased as flaps were reflected for 30,60, or 120 minutes. It is concluded that inflammatory stimuli due to bacterial plaque or tissue trauma both result in lowered tissue cAMP levels which may be one of teh mediators of the physiologic changes seen in gingival tissuess during infalmmation.