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Interaction of inflammatory cells and oral microorganisms
Author(s) -
Tsai C.C.,
Hammond B.F.,
Baehni P.,
McArthur W.P.,
Taichman N.S.
Publication year - 1978
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1978.tb00204.x
Subject(s) - phagocytosis , degranulation , bacteria , microbiology and biotechnology , bacteroides , microorganism , inflammation , gram negative bacteria , dental plaque , pathogenesis , biology , chemotaxis , lysosome , immunology , chemistry , enzyme , biochemistry , genetics , receptor , escherichia coli , gene
The purpose of this study was to asceertain if representative Gram‐negative microorganisms isolated form human dental plaque could stimulate the relesase of lysosomal constituents from human peripheral blood or rabbit peritoneal polymorphonuclear leukocytes(PMNs). All microorganisms tested in this study can act as periodontal pathogens in experimental animals. With the exception of Y4, a Bacteroides‐like Gram‐negative mkicroorganism, all bacteria triggered PMN lysosome release in absence of serum components. Electron microscopic observations indicated that degranulation and release of PMN lysosomes were associated with phagocytosis of Gram‐negative bacteria. Serum had modulating effects on PMN release, generally enhancintg release reactions to all bacteria including Y4. These data suggest that PMN interactions with Gram‐negative bacteria may be one important mechanism in the pathogenesis of gingival and periodontal inflammation.