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Histological changes in experimental periodontal disease in rats monoinfacted with gram‐negative organisms
Author(s) -
Irving J. T.,
Socransky S. S.,
Tanner A. C. R.
Publication year - 1978
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1978.tb00187.x
Subject(s) - eikenella corrodens , periodontium , microbiology and biotechnology , fusobacterium nucleatum , strain (injury) , dental alveolus , capnocytophaga , porphyromonas gingivalis , periodontitis , periodontal disease , biology , weanling , pathology , medicine , dentistry , bacteria , anatomy , endocrinology , genetics
Groups of weanling gnotobiotic rats of the Sprague‐Dawley strain were monoinfected with isolates of Cappocytophaga , strains 4, 6 and 27, and with Fusobacterium nucleatum , strain 325, Bacteroides strain 289c and Eikenella corrodens , strain 1073. All caused periodontal disease between the first and second maxillary molars, with migration of the epithelial attachment, destruction of the alveolar bone by osteoclasts and impaction of debris. No plaque was formed. Capnocytophaga , strain 4, caused almost complete destruction of the periodontium by 42 days. The other organisms were less pathogenic, but all caused considerable destruction of the periodontium by 84 days.