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IgG subclasses in human periodontal disease
Author(s) -
Mackler Bruce F.,
Waldrop Thomas C.,
Schur Peter,
Robertson Paul B.,
Levy Barnet M.
Publication year - 1978
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1978.tb00159.x
Subject(s) - subclass , gingivitis , periodontitis , immunology , antibody , periodontal disease , pathology , medicine , bone marrow , disease , immunoglobulin g , biology , dentistry
Lymphocytes with surface IgG and plasma cells producing IgG have been shown to be a prominent feature of different inflammatory periodontal lesions. The subclass nature of the IgG‐bearing cells in gingival biopsies was investigated in order to further define these inflammatory cell infiltrates and correlate them with different stages of human periodontal disease. Mild gingivitis was characterized by lymphocytes which lacked surface IgG and Fc receptors suggestive of thymus (T) dependent cells. In severe gingivitis, the nature of the localized cellular infiltrate changed with increasing numbers of IgG1 (22%) and IgG3 (17%) labelled lymphocytes, with lesser number of IgG4 (7%) and IgG2 (1%) similar incidence of IgG subclass plasma cells was also observed. Destructive periodontitis was characterized by high numbers of plasma cells (57%) distributed throughout the gingiva. The incidence of IgG subclasses was 25% IgG1, 19% IgG4, 18% IgG3, and 1% IgG2. This distribution of IgG subclass. These findings present further evidence that the cellular infiltrate in the most destructive stage of periodontal disease, priodontitis, is primarily composed of bone marrow (B) derived cells.