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The effect of dietary Gantrisin® supplements on the flora of periodontal pockets in four beagle dogs
Author(s) -
Newman Michael G.,
Sandler Mathew,
Ormerod William,
Angel Leo,
Goldhaber Paul
Publication year - 1977
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1977.tb00115.x
Subject(s) - beagle , periodontitis , anaerobic bacteria , flora (microbiology) , oral microbiology , dental alveolus , anaerobic exercise , medicine , antibiotics , biology , dentistry , physiology , microbiology and biotechnology , bacteria , genetics
The predominant cultivable flora from advanced periodontal pockets (> 4 mm bone loss) was compared with the microbiota isolated from areas of incipient periodontal lesions (< 2 mm bone loss) in Beagle, dogs with periodontal disease. In addition the effect of long term dietary antibiotic (sulfisoxazole) administration on the microbial flora and the clinical course of periodontal disease in these animals was determined. Four male Beagle dogs, 40 months old, had been maintained on a soft diet for 36 months prior to the time of bacterial sampling; two of the animals had been given 44 mg/Kg Gantrisin® (sulfisoxazole) p.o . daily for 3 years. Clinical and radiographic examination of the dogs demonstrated that Gantrisin® seemed to have no effect on the development of periodontitis since both groups exhibited clinical signs of periodontal disease and demonstrated a range of alveolar bone destruction from minimal to severe. Bacterial samples were obtained and cultured from the base of each site utilizing anaerobic techniques. In addition, direct microscopy of whole plaque was carried out. The distribution of the predominant cultivable flora in both treated and non‐treated animals revealed that Gram positive organisms predominated in the incipient lesions, while Gram negative anaerobic rods predominated in advanced periodontal lesions. In all sites anaerobes outnumbered facultatively anaerobic bacteria by at least 2:1.