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Immunoglobulin bearing lymphocytes and plasma cells in human periodontal disease
Author(s) -
Mackler B. F.,
Frostad K. B.,
Robertson P. B.,
Levy B. M.
Publication year - 1977
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1977.tb00107.x
Subject(s) - lamina propria , immunoglobulin d , gingivitis , periodontitis , antibody , immunoglobulin a , pathology , immunology , junctional epithelium , oral mucosa , immunoglobulin g , connective tissue , biology , epithelium , medicine , b cell , dentistry
Gingival biopsies from areas characterized as clinically normal, mild gingivitis, or periodontitis were examined. Immunoglobulin (IgG, IgA, IgM, IgE and IgD) bearing cells at the sulcular and oral epithelium ‐ lamina propria junctions as well as the central lamina propria areas were quantitated. Normal gingiva (P. I. = 0‐0·2) contained few lymphocytes and plasma cells. Biopsies from areas of mild gingivitis (P. I. = 0·2‐1) were infiltrated at the sulcular epithelium ‐ lamina propria junction by lymphocytes lacking membrane associated immunoglobulins (94 %). Few plasma cells were evident. In contrast, tissue associated with periodontitis (P. I. = 4·0–8·0) contained significant numbers of immunoglobulin bearing lymphocytes (78 %, IgG; 9 %, IgM; and 4 % IgA) and plasma cells (67 %, IgG; 24 %, IgM; and 8 % IgA) distributed throughout all three major tissue areas. These findings indicated that the nature of cellular infiltrates differed in mild gingivitis and periodontitis. The presence of predominantly IgG and IgM containing cells in periodontitis had important implications for the contribution of nonspecific effector mechanisms to the destruction of periodontal tissue.