Premium
Collagens of oral soft tissues
Author(s) -
Schneir M.,
Furuto D.,
Berger K.
Publication year - 1976
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1976.tb00076.x
Subject(s) - fibrillogenesis , connective tissue , chemistry , soft tissue , in vitro , endocrinology , oral mucosa , medicine , pathology , biology , biochemistry , anatomy
The rate of collagen synthesis in rat palatal mucosa decreased markedly from 2.5 to 13 weeks of age when determined by an in vitro labelling technique. Beyond 13 weeks of age, the rate of collagen synthesis remained unchanged and at a relatively low level. These results were not a consequence of isotope‐dilution arising from an increase of tissue collagen mass. For other connective tissues an age‐dependent decrease in net collagen synthesis has been observed and, therefore, is not unique for palatal mucosa. The principal finding of this study was that the rate of conversion of salt‐soluble to salt‐insoluble collagen in palatal mucosa increased with age and remained at a high level in adult rats. In contrast, the rate of conversion of salt‐soluble to ‐insoluble collagen has been reported to decline in adult rat skin. Collectively, the data suggest that collagen in soft oral connective tissues undergoes fibrillogenesis with a rapidity that may be more characteristic of tissues during rapid growth or during healing, rather than tissues during a normal adult stage of metabolism.