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Effects of amalgam corrosion products on human cells
Author(s) -
Goldschmidt PaulR.,
Cogen RonaldB.,
Taubman SheldonB.
Publication year - 1976
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1976.tb00058.x
Subject(s) - trypan blue , amalgam (chemistry) , corrosion , hela , chemistry , cytotoxicity , nuclear chemistry , dentistry , biochemistry , medicine , cell , in vitro , organic chemistry , electrode
Using three independent criteria, we have found that 10 −4 ‐10 −6 M concentrations of ions presumably liberated from the corrosion of dental amalgam produce injurious effects on either human gingival fibroblasts or HeLa cells when the cells are grown in culture. Release of 51 Cr and uptake of trypan blue dye were seen with 10 −5 M Hg ++ and Ag + . Inhibition of amino acid incorporation into protein‐like material was seen with eluates of amalgam and with ionic solutions of most metals comprising dental amalgam. Stannous ion showed little if any cytotoxic potential. These results suggest that corrosion products of amalgam are capable of causing cellular injury or destruction.