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The effect of alteration in the sulcular environment upon the movement of 14 C‐diphenylhydantoin through rabbit sulcular tissues
Author(s) -
Steinberg ArnoldD.,
Steinberg June,
Allen Pamela,
Jeffay Henry
Publication year - 1976
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1976.tb00049.x
Subject(s) - gingival sulcus , chemistry , sodium cyanide , sodium fluoride , cyanide , fluoride , dentistry , medicine , inorganic chemistry
The kinetics of uptake and transport into blood after two hours of incubation of diphenylhydantoin (DPH) appears to be of the saturation type, (i.e. linear with the amount of DPH available for transport), but at higher DPH concentration the transport rate is markedly decreased. Insights into the properties of the transport system are gained by studying the effects of substances believed to alter cell membrane properties. The addition of 0.03 M potassium fluoride or 0.03 M sodium cyanide in gingival sulcus significantly alters the uptake of 14 C‐DPH by serum. These findings and use of this methodology have important implications in the study of sulcular tissue physiology and pathology.