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Cell dynamics of experimental gingivitis in macaques
Author(s) -
Johnson N. W.,
Hopps R. M.
Publication year - 1975
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1975.tb00023.x
Subject(s) - gingivitis , immune system , inflammation , immunology , phagocytosis , pathology , delayed hypersensitivity , lymphocyte , macrophage , medicine , biology , dentistry , biochemistry , in vitro
Counts were made of cells present within the inflammatory focus in gingival biopsies from adult macaque monkeys with gingivitis of varying chronicity and severity. Data (Set I) were derived from biopsies taken 3 to 85 days after withdrawal of oral hygiene: during this period the mean gingival index rose from 0.7 to 2.1 but corresponding trends in size and nature of cellular infiltrate were not apparent ‐ the lesions containing 25–40 % macrophages, 20–30 % fibroblasts, 3–30% polymorphonuclear leucocytes, 10 % endothelial cells, 4–9 % lymphocytes and 5–11 % plasma cells. Infiltrates from molar teeth, however, tended to be smaller, to contain relatively more macrophages and fewer lymphocytes and plasma cells than tissue from anterior teeth. These data were compared with those derived from the same animals 5 months later (Set II) and from animals several years older with more severe disease (Set III). With more extensive and more long standing inflammation there were significant increases in plasma cell and polymorphonuclear leucocyte density, and decreases in fibroblasts and macrophages; lymphocyte and endothelial cell densities were relatively stable. The findings are interpreted as a mixed immune inflammatory response in which delayed hypersensitivity mechanisms may initially play a part but in which, as disease progresses, the humoral arm of the immune response seems to he more extensively deployed.