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The fate of vital and devitalized bone grafts in the healing of interradicular lesions
Author(s) -
Ellegaard Birgit,
Karring Thorkild,
Löe Harald
Publication year - 1975
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1975.tb00012.x
Subject(s) - bone decalcification , cancellous bone , transplantation , medicine , molar , dentistry , cementum , osteocyte , anatomy , cementoenamel junction , dentin , biology , surgery , osteoblast , biochemistry , in vitro
The fate of vital and devitalized grafts of mature cancellous bone from the jaws were studied in interradicular lesions in monkeys. 98 bifurcation defects were produced in premolars and molars and maintained by periodontal dressing inserted for four weeks. Ten to 15 weeks later fresh cancellous bone was transplanted into 32 defects. Other cancellous bone grafts were devitalized by boiling and transplanted into 34 bifurcations. The remaining 32 defects received no grafts. The animals were sacrificed to yield observation periods from 0 to 90 days. After decalcification of the specimens and embedding in paraffin; serial sections were cut at 8 microns and stained. The fate of viable and dead transplants were similar during the healing of the interradicular lesions. Except for a few osteocytes which seemed to survive transplantation in the fresh cancellous bone, the osteocyte lacunae were devoid of cells in both types of transplants after 1 week. The deepest located bone grafts became incorporated in new bone developed from the interradicular septum. The more superficially located grafts were rejected or were surrounded by a cementum‐like substans. The influence of the grafts on bone regeneration was small and based solely on their osteoconductive effect.