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Autoradiographic studies of 14 C‐chlorhexidine given orally in mice
Author(s) -
Magnusson B.,
Heyden G.
Publication year - 1973
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1973.tb02164.x
Subject(s) - chlorhexidine , respiratory tract , stomach , alimentary tract , respiratory system , gastrointestinal tract , apposition , stomatitis , chemistry , pharmacology , medicine , dentistry
The distribution of 14 C‐chlorhexidine diacetate and digluconate applied to the back of the mouth in young female mice was studied with apposition autoradiography and liquid emulsion micro‐autoradiography. The uptake after single or repeated doses was observed in animals allowed to survive from 15 minutes to 2 months. The radiolabelled chlorhexidine showed a marked, affinity to the epithelial lining of the alimentary and respiratory tracts. It also appeared in the liver and kidneys. In animals sacrificed 2 weeks after treatment the bulk of the material had left the body. However, even 2 months after a single dose traces could be demonstrated in the respiratory tract, in the secretory mucosa of the stomach and in the kidneys. Chlorhexidine is metabolized and excreted via the same pathways as most foreign compounds. A generalised use of chlorhexidine in the prophylaxis of dental diseases must abide the results of adequate toxicological data.