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Gingival collagen biosynthesis in mongolism
Author(s) -
Claycomb C.K.,
Summers G.W.,
Hall W.B.,
Hart R.W.
Publication year - 1970
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1970.tb01834.x
Subject(s) - hydroxyproline , mongoloid , proline , biosynthesis , periodontitis , medicine , dentistry , periodontal disease , incubation , pathology , chemistry , enzyme , biochemistry , amino acid , population , environmental health
Collagen biosynthesis, as measured by conversion of 3–4 3 H‐proline to 3 H‐hydroxyproline, was studied in excised gingival samples utilizing an in vitro tissue slice incubation technique. Samples of clinically normal gingiva and gingiva affected by periodontitis were studied in ten mongoloid patients and eleven non‐mongoloid mentally normal patients. High 3 H‐proline uptakes were found in all samples of mongoloid gingiva indicating a high level of collagen synthesis. A possible metabolic block in collagen maturation is suggested as an etiologic factor in the severe form of periodontitis observed.