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The effect of hydrocortisone on the concentration and synthesis of acid mucopolysaccharides in the rat gingiva
Author(s) -
Kofoed J.A.,
Bozzini C.E.
Publication year - 1970
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1970.tb00726.x
Subject(s) - glycosaminoglycan , hyaluronic acid , heparin , chondroitin sulfate , hydrocortisone acetate , chemistry , sulfate , chondroitin , hydrocortisone , medicine , endocrinology , body weight , biochemistry , anatomy , organic chemistry
Treatment of adult male rats with hydrocortisone acetate in a dosis of 5 mg/Kg of body weight daily during 20 days produced a decrease in the concentration of hyaluronic acid, chondroitin‐6‐sulfate and heparin in gingiva. These effects are at least partially due to a decrease in the rate of synthesis of such compounds, as measured by incorporation of acetate‐C 14 and sulfate‐S 35 into mucopolysaccharides.