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The in‐vitro sensitivity of oral spirochaetes to metronidazole
Author(s) -
Davies R.M.,
Stirland R.M.
Publication year - 1970
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1970.tb00714.x
Subject(s) - spirochaete , metronidazole , treponema denticola , penicillin , microbiology and biotechnology , treponema , in vitro , medicine , antibiotics , biology , dentistry , periodontitis , immunology , syphilis , bacteria , biochemistry , genetics , porphyromonas gingivalis , human immunodeficiency virus (hiv)
Ten pure strains of oral spirochaetes, having the same morphological and cultural characteristics as Treponema denticola, were isolated from 8 patients with acute necrotizing ulcerative gingivitis (ANUG). Penicillin and Metronidazole were tested for their ability to inhibit growth of these ten strains in vitro. The visual end point was 0.0–0.001 μ/ml for Penicillin and 0.1–0.01 μg/ml for Metronidazole. The significance of these results is discussed in relation to the aetiology and management of ANUG.