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Lack of effect of high doses of fluoride in prevention of alveolar bone loss in rats
Author(s) -
Kristoffersen Tore,
Bang Gisle,
Meyer Knut
Publication year - 1970
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1970.tb00704.x
Subject(s) - fluoride , weanling , sodium fluoride , dental alveolus , dentistry , resorption , bone resorption , chemistry , endocrinology , medicine , inorganic chemistry
Drinking water containing 45 ppm fluoride (as sodium fluoride) was given to 15 male weanling rats for 6 months. A control group, 14 rats, received water containing 0.02 ppm fluoride. The high intake of fluoride had no preventive effect on alveolar bone resorption. Rather, there was a tendency to slightly more alveolar bone loss in the fluoridated rats, particularly in the mandible. The results are discussed in relation to possible toxic systemic effects and possible local injurious effects of high concentrations of fluoride.