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The primary immune response of mice to two submucosal antigens
Author(s) -
Young W. G.,
Dick H. M.,
Trott J. R.
Publication year - 1969
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1969.tb01978.x
Subject(s) - immune system , bovine serum albumin , antibody , ferritin , antigen , lymph , immunology , primary and secondary antibodies , serum albumin , albumin , antibody response , pathology , medicine , biology , chemistry , endocrinology
Within the limits of these experiments there appeared to be a difference in quality of the immune response of mice to Bovine Serum Albumin and Horse Ferritin. A primary injection of Bovine Serum Albumin in the mandibular labial sulcus was followed by cell replication and plasma cell differentiation in the cervical lymph nodes and a rise in serum antibody. No similar quantitatively measurable cellular response was found in the cervical lymph nodes to a primary injection of Horse Ferritin in the same site, although detectable quantities of serum antibody were present in the same animals.