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Influence of sex hormones on gingival exudation in gingivitis‐free female dogs
Author(s) -
Lindhe Jan,
Attström Rolf,
Björn AnnaLisa
Publication year - 1968
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1968.tb01930.x
Subject(s) - hormone , medicine , estrogen , gingivitis , dentistry , physiology , endocrinology
This investigation was undertaken to study the influence of an increased level of estrogen and progesterone upon gingival exudation in gingivitis‐free female dogs. Four female dogs constituted the experimental material. For three weeks prior to the hormone study all were supplied with a hard diet consisting of raw bovine tracheas. In addition, the teeth were cleaned every second day with rubber cups and pumice. During the experimental period gingival fluid was collected from the buccal areas. The intra‐crevicular method was applied in three quadrants and the extra‐crevicular in one quadrant. A total of seven strips from six teeth were measured in each quadrant. Gingival fluid was sampled five times during the course of this study; once immediately before and once seven days after each of the two hormone periods and twice during the course of hormone administration. During the first hormone period comprising 52 hours, each dog was twice given 1 mg estrogen and 25 mg progesterone. During the second hormone period, which also lasted for 52 hours, the dose of each hormone was doubled. The hormones were injected intramuscularly in the hind leg. The results show that when the intra‐crevicular technique of sampling was used, the administration of estrogen and progesterone induced an increased flow of gingival fluid. The increased gingival exudation was observed in all four dogs and occurred in both of the hormone periods. At the end of the period of sex hormone administration the gingival exudation returned to normal. The present study also showed that no influence of sex hormones on gingival exudation could be demonstrated by the extra‐crevicular sampling method.