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The effect of hypervitaminosis D on the periodontal membrane collagen in lathyritic rats
Author(s) -
Shoshan Shmuel,
Pisanti Sarah,
Sciaky Ino
Publication year - 1967
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1967.tb01880.x
Subject(s) - connective tissue , hypervitaminosis a , lathyrism , endocrinology , medicine , vitamin , hypervitaminosis , chemistry , vitamin d and neurology , calcium , retinol , pathology
Toxic doses of vitamin D 2 (5 × 1 U) were administered to lathyritic rats which received aminoacetonitrile in drinking water for 15 days. The peridontal membrane (PDM) of the molars was examined both histologically and biochemically. The PDM collagen of the lathyritic animals could be extracted with cold 0.15 M NaCI, whereas that of the normal controls, or of the animals which received either the vitamin alone or both the lathyrogen and the vitamin was not extractable. Ossification of the PDM and supraalveolar connective tissue was apparent in the lathyritic group which received toxic doses of the vitamin but not in either lathyrism or hypervitaminosis alone. It is concluded that whereas the release of calcium from bone or the increased absorption of the mineral from the intestine is affected by vitamin D, its deposition in the soft connective tissues may depend on the nature of the protein matrix.