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The oxytalan connective tissue fibres in gingival hyperplasia in patients treated with sodium diphenyl‐hydantoin
Author(s) -
Baratieri Antonio
Publication year - 1967
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1967.tb01878.x
Subject(s) - connective tissue , epithelium , hyperplasia , pathology , chemistry , anatomy , medicine
Oxytalan fibres in hyperplastic gingival papillae from 12 young epileptics who had been treated with sodium diphenyl‐hydantoin were studied with modifications of Fullmer and Lillie's (1958) and Löe and Nuki's (1964) staining methods. These fibres were compared with the fibres in clinically normal gin‐givac and in tissue from fibrous epulides. Fibres reacting with peracetic acid‐aldehyde fuchsin (i.e. oxytalan fibres) were present throughout the connective tissue and were especially numerous near the surface epithelium and in areas of inflammatory infiltration. The oxytalan fibres were especially prominent along the junction with epithelium, between the rete pegs and in the deeper connective tissue near bone where they tended to be arranged in large parallel bundles. In cases of fibrous epulis, however, there were very few oxytalan fibres in the connective tissue adjacent to the surface epithelium. It is concluded that the connective tissue performs an important supportive function to the epithelium in gingival hyperplasia, and is of special importance in the genesis of gingival hyperplasia in patients under treatment with sodium diphenyl‐hydantoin.