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An evaluation of the effects of collagen implants on new bone formation in vivo
Author(s) -
Solomons C. C.,
Gregory G. W.
Publication year - 1966
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1966.tb01863.x
Subject(s) - tetracycline , in vivo , pepsin , chemistry , bone formation , tetracycline hydrochloride , dentistry , biochemistry , endocrinology , antibiotics , biology , enzyme , medicine , microbiology and biotechnology
Certain polypeptides have been shown to accelerate the formation of hydroxapatite crystals in virto. This investigation was designed to evaluate this phenomenon in vivo. Ox bone citrate‐soluble collagen, by itself and pepsin treated, was implanted into small artifically produced defects in the maxillae of 35 rats. An indication of subsequent new bone formation was obtained by measuring the uptake of tetracycline by the defects at definite intervals after implantation. By the end of 14 days, tetracycline uptake by defects filled with untreated collagen reached a maximum of 17 times that of unimplanted controls. By 10 days, pepsin treated collagen accelerated tetracycline uptake 18 times control values. The tetracycline content in both the experimental and control defects was essentially the same after 35 days. From this experiment it is concluded that citrate‐soluble collagen accelerated bone mineral deposition.