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The effect of sex hormones on inflammation
Author(s) -
Lindhe J.,
Sonesson B.
Publication year - 1966
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1966.tb01862.x
Subject(s) - granuloma , croton oil , progestogen , hormone , connective tissue , pouch , inflammation , endocrinology , medicine , relaxin , chemistry , pathology , anatomy
The present investigation was concerned with the effect of the progestogen hormone, Duphaston R , on the inflammatory reaction of rats. The granuloma pouch technique elaborated by Selye was used. The injection of 25 ml of air into the dorsum of the rat created a subcutaneous sac, into which the hormone and the irritant were deposited. Injections of 1 % solution of croton oil (the irritant) into this sac produced a pronounced inflammatory reaction in the connective tissue of the wall of the sac and formed a thick granulomatous membrane. If the progestogen was deposited into the granuloma pouch at the same time as the eroton oil or on the previous day, the membrane, compared with that induced solely by the croton oil was much thinner. Progestogen itself injected into the air sac produced no granulomatous membrane at all. These results seem to indicate that the hormone progestogen may depress the inflammatory reaction of the connective tissue induced by the croton oil. In current experiments the effect of estradiol, gonadotropin and relaxin on the granuloma pouch inflammation is being studied.