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Dynamics of the inflammatory reaction
Author(s) -
SchultzHaudt Stig D.,
Sölna Josrein
Publication year - 1966
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/j.1600-0765.1966.tb01861.x
Subject(s) - histamine , vascular permeability , inflammation , mediator , liberation , immunology , wound healing , chemistry , medicine , microbiology and biotechnology , biology , pathology , biochemistry , pharmacology , in vitro
Regardless of the type of tissue injury, the resulting inflammatory reaction usually follows a regular pattern composed of two distinct phases. The first phase, which occurs immediately upon injury, involves a temporarily increased permeability of the small vessels, mainly the venules. of the afflicted area. This rapidly wanes, whereafter the second phase of the reaction ensues. This comprises a prolonged increase of capillary permeability along with a progressive emigration of leucocytes for quit some hours. The further course of the reaction is determined by the type of the injurious agent as well as by the general status of health of the tissues and their previous experience with the injurious agent in question. It is generally agreed that the inflammatory reaction is induced and mediated by a number of biologically active substances, called mediators, which become activated or released upon tissue injury. It appears that the liberation of histamine is essential for the first phase of inflammation to take place. The course of the second phase is determined by several mediators, since there is accumulating evidence to the effect that increased capillary permeability and emigration of leucocytes are, at least in part, due to different types of mediator substances. The available evidence suggests that increased proteolytic activity is intimately involved with the progress of the inflammory reaction and is essential for wound healing.