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Induction of the immune response to periodontopathic bacteria and its role in the pathogenesis of periodontitis
Author(s) -
ISHIKAWA ISAO,
NAKASHIMA KEISUKE,
KOSEKI TAKEYOSHI,
NAGASAWA TOSHIYUKI,
WATANABE HISASHI,
ARAKAWA SHINICHI,
NITTA HIROSHI,
NISHIHARA TATSUJI
Publication year - 1997
Publication title -
periodontology 2000
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.725
H-Index - 122
eISSN - 1600-0757
pISSN - 0906-6713
DOI - 10.1111/j.1600-0757.1997.tb00193.x
Subject(s) - correct name , medicine , periodontitis , citation , inflammatory response , immune system , library science , biology , immunology , computer science , inflammation , dentistry , paleontology
Periodontitis results from infection with subgingival plaque-forming bacteria followed by host immune responses. Recent data indicate that Porphyromonas gingivalis, Actinobacillus actinomycetemcornitans and Bacteroides forsythus initiate and progress periodontitis (1). Pgingivalisis mostly found in deep periodontal pockets and especially in active sites (111, 212, 239). A. actinomycetemcomitans is found in pockets from patients with localized juvenile periodontitis as well as advanced adult periodontitis (72). B. forsythus seems to be related to disease activity (46, 235). Progress of the disease is arrested or slowed and the clinical condition is ameliorated by eliminating or decreasing the numbers of these bacteria (187). Bacterial ecology and immune responses in periodontal pockets are complex. Therefore, it is unlikely that only these three bacteria are the causative agents of periodontitis. However, exceeding a particular threshold or a rapid increase in the number of these three types of bacteria are closely related to the breakdown of periodontal tissues. The objective of this chapter is to summarize current understanding of the immune response induced by these bacteria and its role in the pathogenesis of periodontitis.